FITC标记的锚蛋白重复结构域47抗体
产品名称： FITC标记的锚蛋白重复结构域47抗体
英文名称： Anti-ANKRD47/FITC
产品编号： HZ-17218R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ANKRD47/FITC Conjugated antibody
FITC标记的锚蛋白重复结构域47抗体
| 英文名称 | Anti-ANKRD47/FITC |
| 中文名称 | FITC标记的锚蛋白重复结构域47抗体 |
| 别 名 | ANKRD47; Ankyrin repeat domain 47; Ankyrin repeat domain containing protein 47; Ankyrin repeat domain-containing protein 47; FLJ46061; KANK3; KANK3_HUMAN; Kidney ankyrin repeat containing protein 3; KN motif and ankyrin repeat domain containing protein 3; KN motif and ankyrin repeat domain-containing protein 3; KN motif and ankyrin repeat domains 3; Ng28. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 88kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ANKRD47 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Mutations of ankyrin genes lead to severe genetic diseases, such as fatal cardiac arrhythmias and hereditary spherocytosis. ANKRD47 an 840 amino acid coiled-coil protein that contains five ANK repeats and exists as two alternatively spliced isoforms. Conserved in chimpanzee, dog, cow, mouse and rat, ANKRD47 is expressed in breast, liver, lung, skeletal muscle and kidney. ANKRD47 assists in the formation of actin stress fibers and is encoded by a gene that maps to human chromosome 19p13.2. Chromosome 19 makes up over 2% of the human genome and contains approximately 63 million bases, which encode over 1,400 genes. Recognized for having the greatest gene density of all human chromosomes, chromosome 19 is linked to Peutz-Jeghers syndrome, spinocerebellar ataxia type 6, the stroke disorder CADASIL, hypercholesterolemia and insulin-dependent diabetes Function: May be involved in the control of cytoskeleton formation by regulating actin polymerization. Tissue Specificity: Strongly expressed in breast, liver, lung, skeletal muscle and kidney. Similarity: Contains 5 ANK repeats. Database links: Entrez Gene: 256949 Human Entrez Gene: 80880 Mouse Entrez Gene: 366848 Rat Omim: 614611 Human SwissProt: Q6NY19 Human SwissProt: Q9Z1P7 Mouse Unigene: 322473 Human Unigene: 196330 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
强直蛋白是膜适配分子，在将完整的膜蛋白与基于光谱的细胞骨架网络连接中起重要作用。锚蛋白基因突变导致严重的遗传性疾病，如致命性心律失常和遗传性球形红细胞增多症。AKRD47一种840氨基酸卷曲蛋白，含有五个重复序列，并作为两个交替剪接的异构体存在。在黑猩猩、狗、牛、小鼠和大鼠中，AKRD47在乳腺、肝、肺、骨骼肌和肾脏中均有表达。AKRD47协助形成肌动蛋白应力纤维，并被编码到人类染色体19p132的基因编码。第19号染色体占人类基因组的2%以上，约有6300万个碱基，编码1400个基因。19号染色体被认为是人类所有染色体中最大的基因密度，它与Peutz-Jeghers综合征、脊髓小脑共济失调6型、中风病CADASIL、高胆固醇血症和胰岛素依赖型糖尿病有关。