Active HDAC3+NCOR2 complex全长蛋白质-蛋白质/抗原/多肽-试剂-生物在线
深圳市宇德立生物科技有限公司
Active HDAC3+NCOR2 complex全长蛋白质

Active HDAC3+NCOR2 complex全长蛋白质

商家询价

产品名称： Active HDAC3+NCOR2 complex全长蛋白质

英文名称： CTG26 HD 3 HD3 HDAC 3 HDAC3 HDAC3_HUMAN Histone deacetylase 3 NCOR 2 Nuclear receptor co repressor 2 RPD3 RPD3-2 SMAP45 SMRTE SMRTE tau TNRC

产品编号： ab42631

产品价格： 0

产品产地： 英国

品牌商标： abcam

更新时间： null

使用范围： null

深圳市宇德立生物科技有限公司
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  • 地址 : 深圳市宝安区西乡宝民二路贤基大厦4E
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  • 所在区域 : 广东
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进入展台

 

  • 性质Recombinant
  • 来源Baculovirus

技术指标

Our Abpromise guarantee covers the use of ab42631 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性Activity: 110 U/ug. One U =1 pmol/min, Assay condition: 25 mM Tris/Cl, pH8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, and 0.1 mg/ml BSA, 30 uM Biomol substrate (Catalog number KI177), and 1 ng/ul HDAC3/NcoR2. Incubation condition: 30 min at 37ºC.
  • 应用

    Inhibition Assay

  • 纯度> 90 % by SDS-PAGE.

  • 形式Liquid
  • 补充说明Co-expressed in a Baculovirus infected Sf9 cell expression system.
  • 浓度50 µg 浓度为 1.1 mg/ml 

制备和贮存

  • 稳定性和存储

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 10% Glycerol, 50mM Tris HCl, 20mM Glutathione, 138mM Sodium chloride, pH 8

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • CTG26
    • HD 3
    • HD3
    see all
  • 功能Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation.
  • 组织特异性Widely expressed.
  • 序列相似性Belongs to the histone deacetylase family. HD type 1 subfamily.
  • 翻译后修饰Sumoylated in vitro.
  • 细胞定位Nucleus.