FITC标记的细胞色素P450 1A2抗体
产品名称： FITC标记的细胞色素P450 1A2抗体
英文名称： Anti-P450 1A2/FITC
产品编号： HZ-2589R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-P450 1A2/FITC Conjugated antibody
FITC标记的细胞色素P450 1A2抗体
| 英文名称 | Anti-P450 1A2/FITC |
| 中文名称 | FITC标记的细胞色素P450 1A2抗体 |
| 别 名 | CYP1A2; Cytochrome P450 1A2; cytochrome P450, family 1, subfamily a, polypeptide 2; Cytochrome P450 family 1 polypeptide 2; Cytochrome P450 subfamily I aromatic compound inducible polypeptide 2; Cyp1a2; CYPD45; P-450d; RATCYPD45; CYP1A2; CP12; CP 12; P3-450; Aryl hydrocarbon hydroxylase; Dioxin inducable P3 45; Flavoprotein linked monooxygenase; Microsomal monooxygenase; P450 4; P450 form 4; P450 P3; P450(PA); Xenobiotic monooxygenase. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 合成与降解 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 56kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human P450 1A2/CYP1A2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu region. [provided by RefSeq].sequences flanked by direct repeats in the 3' untranslated. Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin. Subcellular Location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Tissue Specificity: Liver. Similarity: Belongs to the cytochrome P450 family. Database links: Entrez Gene: 1544 Human Entrez Gene: 13077 Mouse Entrez Gene: 24297 Rat Omim: 124060 Human SwissProt: P05177 Human SwissProt: P00186 Mouse SwissProt: P04799 Rat Unigene: 1361 Human Unigene: 15537 Mouse Unigene: 5563 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 合成与降解（Synthesis and Degradation） |
该基因编码细胞色素P450酶家族的一个成员。细胞色素P450蛋白是单加氧酶，催化许多药物代谢和胆固醇、类固醇和其他脂类的合成反应。该基因编码的蛋白质定位于内质网，其表达是由一些多环芳烃（PAHs）引起的，其中一些是在香烟烟雾中发现的。酶的内源性底物是未知的，然而，它能够代谢一些多环芳烃致癌致癌中间体。这种酶的其他异源底物包括咖啡因、黄曲霉毒素B1和对乙酰氨基酚。该基因的转录包含四个ALU区域。序列由3′非翻译中的直接重复组成。