FITC标记的同源盒基因HOXA7蛋白抗体
产品名称： FITC标记的同源盒基因HOXA7蛋白抗体
英文名称： Anti-HOXA7/FITC
产品编号： HZ-11295R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-HOXA7/FITC Conjugated antibody
FITC标记的同源盒基因HOXA7蛋白抗体
| 产品编号 | bs-11295R-FITC |
| 英文名称 | Anti-HOXA7/FITC |
| 中文名称 | FITC标记的同源盒基因HOXA7蛋白抗体 |
| 别 名 | ANTP; Homeobox A7; Homeobox protein Hox 1.1; Homeobox protein Hox A7; Homeobox protein Hox-1A; Homeobox protein Hox-A7; HOX1; Hox1A; HOXA7; HXA7_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 细胞生物 神经生物学 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 25kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HOXA7 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: HOX genes play a fundamental role in the development of the vertebrate central nervous system, heart, axial skeleton, limbs, gut, urogenital tract and external genitalia. The homeobox gene Hoxa-1 is transcriptionally regulated by retinoic acid (RA) and encodes a transcription factor, which has been shown to play important roles in cell differentiation and embryogenesis. Hoxa-1 is also expressed in cancers, such as mammary tumors, though it is not expressed in normal gland or in precancerous mammary tissues. At embryonic stages, Hoxa-2 is expressed in the mesenchyme and epithelial cells of palate, however its expression is restricted to the tips of the growing palatal shelves. Hoxa-2 protein is predominantly expressed in the nuclei of cells in the ventral mantle region of the developing embryo. In the developing and adult mouse spinal cord, Hoxa-2 protein may contribute to dorsal-ventral patterning and/or to the specification of neuronal phenotype. Hoxa-7 functions as a potent transcriptional repressor and its action as such requires several domains, including both activator and repressor regions. Hoxa-7 is expressed in the fetal liver, lung, skeletal muscle, kidney, pancreas and placenta. Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Subcellular Location: Nucleus. DISEASE: Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain. Database links: Entrez Gene: 3204 Human Entrez Gene: 500126 Rat Omim: 142950 Human SwissProt: P31268 Human SwissProt: P09634 Rat Unigene: 610216 Human Unigene: 660918 Human Unigene: 203714 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Hox基因在脊椎动物中枢神经系统、心脏、轴心骨骼、四肢、肠道、泌尿生殖道和外生殖器的发育中起着基础性的作用。同源盒基因HOXA-1通过视黄酸（RA）转录调控，编码转录因子，在细胞分化和胚胎发生中起着重要作用。HOXA-1也在乳腺癌等肿瘤中表达，但在正常腺或癌前乳腺组织中未表达。在胚胎期，HOXA-2在腭间质和上皮细胞中表达，但其表达仅限于生长腭架的尖端。HOXA-2蛋白主要在发育中的胚胎的腹幔区的细胞核中表达。在发育和成年小鼠脊髓中，HOXA-2蛋白可能有助于背腹构图和/或神经元表型的规范。HOXA-7作为强有力的转录阻遏物发挥作用，其作用需要几个域，包括激活剂和阻遏区。HOXA-7在胎儿肝脏、肺、骨骼肌、肾脏、胰腺和胎盘中均有表达。